Virginia Tech won't be able to focus exclusively on Heintschel.
Pitt has distributed the football throughout its offense, with 17 different players recording at least one reception through four games.
Censere Lee and Bryce Yates are tied for the team lead with 13 receptions. Lee has caught four touchdowns, while Yates has produced 193 receiving yards.
Cataurus Hicks has been Pitt's biggest downfield threat, turning 12 receptions into 252 yards. Tight end Carson Kent adds another option with 11 catches for 154 yards and a touchdown.
The Panthers will be without Malik Knight, however, after the Western Carolina transfer was ruled out for Friday's game.